Impact of Coriander Seeds Extract Against Thyroidectomy Induced Testicular Damage and DNA Replication in Male Rats

An important target organ for thyroid hormone activity is the testis and hypo or hyperthyroidism causes noticeable alterations in testicular function. This study aimed to investigate therapeutic effect of Coriander Seeds Extract (CSE) against thyroidectomy induced toxicity, oxidative stress, injury, proliferation male testes rats. 40 rats were equally divided into 4 groups [Gp1, control; Gp2, CSE; Gp3, thyroidectomies (Thy); Gp4, treated with coriander (Thy + CSE)]. Current results revealed after 3 weeks thyroidectomy; a significant (p<0.05) elevation TSH, total T4, serum AST, ALP, non-progressive motility immotile sperms, MDA, reduction T3, sexual hormones (testosterone, FSH, LH, prolactin), sperms parameters (count, morphological index, vitality, progressive motility), GSH, SOD, GST PCNA expressions when compared control. Thy CSE modulates most changes recovery injury. We can conclude that; seed extract could enhance produced toxicity stress through its positive effects scavenging free radicals.